A minimal view of single-particle imaging with X-ray lasers
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| Authors | N. Duane Loh |
| Journal/Conference Name | Philosophical Transactions of the Royal Society B: Biological Sciences |
| Paper Category | Agricultural and Biological Sciences |
| Paper Abstract | The ability to serially interrogate single biomolecules with femtosecond X-ray pulses from free-electron lasers has ushered in the possibility of determining the three-dimensional structure of biomolecules without crystallization. However, the complexity of imaging a sample's structure from very many of its noisy and incomplete diffraction data can be daunting. In this review, we introduce a simple analogue of this imaging workflow, use it to describe a structure reconstruction algorithm based on the expectation maximization principle, and consider the effects of extraneous noise. Such a minimal model can aid experiment and algorithm design in future studies. |
| Date of publication | 2014 |
| Code Programming Language | C |
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