A simulation study comparing modeling approaches in an illness-death multi-state model
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| Authors | Luís Meira-Machado, Susana Faria |
| Journal/Conference Name | Communications in Statistics - Simulation and… |
| Paper Category | Other |
| Paper Abstract | In many medical studies, there are covariates that change their values over time and their analysis is most often modeled using the Cox regression model. However, many of these time-dependent covariates can be expressed as an intermediate event, which can be modeled using a multi-state model. Using the relationship of time-dependent (discrete) covariates and multi-state models, we compare (via simulation studies) the Cox model with time-dependent covariates with the most frequently used multi-state regression models. This article also details the procedures for generating survival data arising from all approaches, including the Cox model with time-dependent covariates. |
| Date of publication | 2014 |
| Code Programming Language | R |
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